The effect of hepatitis C virologic clearance on cardiovascular disease biomarker lipoprotein-associated phospholipase A2 and its relation to serum lipids

نویسندگان

چکیده

Abstract Background Chronic hepatitis C virus (HCV) infection has been linked to cardiovascular disease (CVD). However, CVD risk prediction in chronic HCV-infected patients is problematic as the prevalence of different cardiac biomarkers these currently unknown. Serum lipids, which are routinely used traditional scores, may underestimate patients, while non-hepatically produced biomarkers, including lipoprotein-associated phospholipase A2 (Lp-PLA2), better reflect risk. In this study, we aimed evaluate effect sustained virologic response (SVR) on risk, predicted by Lp-PLA2 mass comparison with serum lipid levels. Results Ninety were enrolled study. was measured before and after HCV treatment via direct-acting antivirals compared changes lipids Framingham score (FRS). The level categorized into high (>235 ng/ml) or low (≤235 ng/ml). Mean significantly decreased from 322.37 ± 79.15 ng/ml 263.79 51.804 SVR, number high-risk dropped 82.22 60% treatment. Total cholesterol, low-density lipoprotein, high-density lipoprotein levels low/optimal at baseline (170 40.34 mg/dl, 71.98 24.12 48.43 6.79 mg/dl) increased SVR (195.66 55.68 103.24 46.57 53.91 8.67 mg/dl). According FRS, only 30% moderate/high insignificantly declined 28.89% post-treatment. Conclusion be a predictor patients. Furthermore, reduce hepatic inflammation consequently

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ژورنال

عنوان ژورنال: Egyptian Liver Journal

سال: 2021

ISSN: ['2090-6226', '2090-6218']

DOI: https://doi.org/10.1186/s43066-021-00110-x